Lens retrodots and vacuoles and their associations with the prevalence and incidence of age-related cataract

Aim To assess the prevalence of retrodots and vacuoles and their associations with the prevalence and long-term incidence of age-related cataract in an older Australian cohort. Methods Of 3654 baseline participants of the Blue Mountains Eye Study aged 49+ years (1992–1994), 2335 and 1952 were re-exa...

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Bibliographic Details
Published in:Eye (London) 2012-04, Vol.26 (4), p.568-575
Main Authors: Tan, A G, Mitchell, P, Rochtchina, E, Hong, T, Cumming, R G, Wang, J J
Format: Article
Language:English
Subjects:
Age Distribution
Aged
Aged, 80 and over
Aging - physiology
Australia - epidemiology
Biological and medical sciences
Cataract - epidemiology
Cataract - pathology
Cataract - physiopathology
Clinical Study
Cross-Sectional Studies
Female
Humans
Incidence
Laboratory Medicine
Lens diseases
Lens, Crystalline - pathology
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Miscellaneous
Ophthalmology
Pharmaceutical Sciences/Technology
Prevalence
Surgery
Surgical Oncology
Visual Acuity - physiology
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Summary:Aim To assess the prevalence of retrodots and vacuoles and their associations with the prevalence and long-term incidence of age-related cataract in an older Australian cohort. Methods Of 3654 baseline participants of the Blue Mountains Eye Study aged 49+ years (1992–1994), 2335 and 1952 were re-examined after 5 and 10 years, respectively. Lens photographs were graded for cataract, retrodots, and vacuoles. Eye-specific data were used to assess the associations between retrodots or vacuoles at baseline and the prevalence and 10-year incidence of nuclear, cortical, and posterior subcapsular (PSC) cataract and cataract surgery. Results At baseline, retrodots were present in 142 persons (4%) and vacuoles in 1333 persons (40%). Prevalence of both lens features increased with increasing age ( P for trend
ISSN:0950-222X
1476-5454
DOI:10.1038/eye.2011.349