Amplitude and timing of somatosensory cortex activity in task-specific focal hand dystonia

Highlights ► This study explores processing anomalies in somatosensory cortex in task-specific focal hand dystonia (tspFHD) using magnetoencephalography (MEG). ► In tspFHD, deviations in response latency and amplitude were identified in both primary and secondary somatosensory cortex across the two...

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Published in:Clinical neurophysiology 2011-12, Vol.122 (12), p.2441-2451
Main Authors: Dolberg, Rebecca, Hinkley, Leighton B.N, Honma, Susanne, Zhu, Zhao, Findlay, Anne M, Byl, Nancy N, Nagarajan, Srikantan S
Format: Article
Language:English
Subjects:
Aberrant evoked sensory responses
Adult
Aged
Biological and medical sciences
Dystonic Disorders - physiopathology
Electrodiagnosis. Electric activity recording
Evoked Potentials, Somatosensory - physiology
Female
Focal hand dystonia
Fundamental and applied biological sciences. Psychology
Hand - physiopathology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Magnetoencephalography
Male
Medical sciences
Middle Aged
Muscle Strength - physiology
Muscle, Skeletal - physiopathology
Nervous system
Neuroimaging
Neurology
Psychomotor Performance - physiology
Reaction Time - physiology
Somatosensory Cortex - physiology
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Vertebrates: nervous system and sense organs
Young Adult
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Summary:Highlights ► This study explores processing anomalies in somatosensory cortex in task-specific focal hand dystonia (tspFHD) using magnetoencephalography (MEG). ► In tspFHD, deviations in response latency and amplitude were identified in both primary and secondary somatosensory cortex across the two hemispheres (ipsi- and contralateral to the affected hand). ► Aberrant response properties are certainly related to impairments of tactile acuity, motor speed and strength; information that can be used to guide future behavioral interventions.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2011.05.020