Ten-Year Risk of Diagnostic Mammograms and Invasive Breast Procedures After Breast-Conserving Surgery for DCIS

• Published in: JNCI : Journal of the National Cancer Institute 2012-04, Vol.104 (8), p.614-621
• Main Authors: NEKHLYUDOV, Larissa, HABEL, Laurel A, ACHACOSO, Ninah, JUNG, Inkyung, HAQUE, Reina, COLLINS, Laura C, SCHNITT, Stuart J, QUESENBERRY, Charles P, FLETCHER, Suzanne W
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Breast Neoplasms - diagnosis; Breast Neoplasms - epidemiology; Breast Neoplasms - surgery; Breasts; Carcinoma, Intraductal, Noninfiltrating - diagnosis; Carcinoma, Intraductal, Noninfiltrating - surgery; Delivery of Health Care, Integrated - statistics & numerical data; Early Detection of Cancer; Female; Follow-Up Studies; Genital system. Mammary gland; Humans; Incidence; Investigative techniques, diagnostic techniques (general aspects); Mammography; Mammography - statistics & numerical data; Mastectomy, Segmental; Medical sciences; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - prevention & control; Oncology; Patient Selection; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Risk Assessment; Risk Factors; SEER Program; Surgery; Time Factors; Tumors; United States - epidemiology; Women
• ISSN: 0027-8874; 1460-2105
• DOI: 10.1093/jnci/djs167

Breast-conserving surgery (BCS) is the most common treatment for ductal carcinoma in situ (DCIS); however, how often women experience subsequent diagnostic evaluations over time is not known. We identified 2948 women with DCIS who were treated with BCS from 1990 to 2001 and followed for up to 10 years at three integrated health-care delivery systems. We calculated the percentages of diagnostic mammograms and ipsilateral invasive procedures following the initial breast excision to treat DCIS, estimated the 10-year cumulative incidence of these procedures, and determined hazard ratios for both types of procedures with Cox regression modeling. All statistical tests were two-sided. Over 10 years, 907 women (30.8%) had 1422 diagnostic mammograms and 1813 (61.5%) had 2305 ipsilateral invasive procedures. Diagnostic mammograms occurred in 7.3% of women in the first 6 months and continued at a median annual rate of 4.3%. Ipsilateral invasive procedures occurred in 51.5% of women in the first 6 months and continued at a median annual rate of 3.1%. The estimated 10-year cumulative risk of having at least one diagnostic mammogram after initial DCIS excision was 41.0% (95% confidence interval [CI] = 38.5% to 43.5%); at least one invasive procedure, 65.7% (95% CI = 63.7% to 67.8%); and either event, 76.1% (95% CI = 74.1% to 78.1%). Excluding events in the first 6 months following initial DCIS excision, corresponding risks were 36.4% (95% CI = 33.8% to 39.0%) for diagnostic mammograms, 30.4% (95% CI = 26.9% to 33.8%) for invasive procedures, and 49.5% (95% CI = 45.6% to 53.5%) for either event. Women with DCIS treated with BCS continue to have diagnostic and invasive breast procedures in the conserved breast over an extended period. The frequency of ongoing diagnostic breast evaluations should be included in discussions about treatment.