Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility

Our genome-wide association study of schizophrenia found association signals at the Kalirin gene (KALRN) and EPH receptor B1 gene (EPHB1) in a Japanese population. The importance of these synaptogenic pathway genes in schizophrenia is gaining independent supports. Although there has been growing int...

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Bibliographic Details
Published in:Schizophrenia bulletin 2012-05, Vol.38 (3), p.552-560
Main Authors: KUSHIMA, Itaru, NAKAMURA, Yukako, INADA, Toshiya, HASHIMOTO, Ryota, TAKEDA, Masatoshi, KAIBUCHI, Kozo, IWATA, Nakao, OZAKI, Norio, ALEKSIC, Branko, IKEDA, Masashi, ITO, Yoshihito, SHIINO, Tomoko, OKOCHI, Tomo, FUKUO, Yasuhisa, UJIKE, Hiroshi, SUZUKI, Michio
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Association analysis
Biological and medical sciences
Exons - genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study - methods
Genotype
Guanine Nucleotide Exchange Factors - genetics
Humans
Japan - epidemiology
Male
Medical sciences
Middle Aged
Mutation, Missense - genetics
Protein Serine-Threonine Kinases - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Receptor, EphB1 - genetics
Regular
Risk Factors
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
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Summary:Our genome-wide association study of schizophrenia found association signals at the Kalirin gene (KALRN) and EPH receptor B1 gene (EPHB1) in a Japanese population. The importance of these synaptogenic pathway genes in schizophrenia is gaining independent supports. Although there has been growing interest in rare (
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/sbq118