Effect of growth hormone-release inhibiting hormone on hormones stimulating exocrine pancreatic secretion

The nature and extent of growth hormone-release inhibiting hormone (GH-RIH, somatostatin)-induced inhibition of pancreatic secretion of bicarbonate and protein, an index of enzyme secretion, were studied by administration of exogenous secretin or cholecystokinin (CCK) and of a number of stimulants f...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of clinical investigation 1976-07, Vol.58 (1), p.1-6
Main Authors: Konturek, S J, Tasler, J, Obtulowicz, W, Coy, D H, Schally, A V
Format: Article
Language:English
Subjects:
Animals
Bicarbonates - secretion
Cholecystokinin
Depression, Chemical
Dogs
Dose-Response Relationship, Drug
Gastric Fistula
Gastric Juice - secretion
Oleic Acids - pharmacology
Pancreas - secretion
Pancreatic Fistula
Peptides
Proteins - secretion
Secretin
Somatostatin - pharmacology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The nature and extent of growth hormone-release inhibiting hormone (GH-RIH, somatostatin)-induced inhibition of pancreatic secretion of bicarbonate and protein, an index of enzyme secretion, were studied by administration of exogenous secretin or cholecystokinin (CCK) and of a number of stimulants for endogenous release of these hormones in fasted pancreatic fistula dogs with and without an infusion of GH-RIH. The results of this study show that GH-RIH inhibits the pancreatic fluid and bicarbonate secretion induced by duodenal acidification and exogenous secretion. The kinetic analysis shows that the interaction between GH-RIH and secretin affecting pancreatic bicarbonate secretion possesses the characteristics of competitive inhibition. GH-RIH does not change the pancreatic protein response to exogenous CCK, but profoundly inhibits pancreatic response to a variety of the endogenous stimulants of CCK release, including duodenal perfusion of sodium oleate, amino acid mixture, or feeding of a peptone meal. We conclude that GH-RIH is a very potent inhibitor of the endogenous release of CCK from the intestinal mucosa and inhibits competitively the action of secretin but not CCK on the exocrine pancreatic secretion.
ISSN:0021-9738
DOI:10.1172/JCI108438