Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice

This study investigated the antidepressant activity of ethanolic extract of U. lanosa Wallich var. appendiculata Ridsd (ULEtOH) for two-weeks administrations by using FST and TST on mice. In order to understand the probable mechanism of antidepressant-like activity of ULEtOH in FST and TST, the rese...

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Published in:Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-12
Main Authors: Peng, Wen-Huang, Cheng, Ying-Hui, Lin, Yu-Chin, Chang, Ching-Wen, Cheng, Hao-Yuan, Ko, Yu-Jen, Hsu, Lieh-Ching, Hsieh, Ming-Tsuen
Format: Article
Language:English
Subjects:
Amine oxidase (flavin-containing)
Antidepressants
Brain research
Bupropion
Chinese medicine
Dopamine
Drugs
Fluoxetine
Hippocampus
Hypothalamus
Imipramine
Ischemia
Ketanserin
Laboratory animals
Maprotiline
Mental depression
Mice
Monoamines
Neostriatum
Pharmacology
Psychopharmacology
Serotonin
Swimming
Uncaria
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Summary:This study investigated the antidepressant activity of ethanolic extract of U. lanosa Wallich var. appendiculata Ridsd (ULEtOH) for two-weeks administrations by using FST and TST on mice. In order to understand the probable mechanism of antidepressant-like activity of ULEtOH in FST and TST, the researchers measured the levels of monoamines and monoamine oxidase activities in mice brain, and combined the antidepressant drugs (fluoxetine, imipramine, maprotiline, clorgyline, bupropion and ketanserin). Lastly, the researchers analyzed the content of RHY in the ULEtOH. The results showed that ULEtOH exhibited antidepressant-like activity in FST and TST in mice. ULEtOH increased the levels of 5-HT and 5-HIAA in cortex, striatum, hippocampus, and hypothalamus, the levels of NE and MHPG in cortex and hippocampus, the level of NE in striatum, and the level of DOPAC in striatum. Two-week injection of IMI, CLO, FLU and KET enhanced the antidepressant-like activity of ULEtOH. ULEtOH inhibited the activity of MAO-A. The amount of RHY in ULEtOH was 17.12 mg/g extract. Our findings support the view that ULEtOH exerts antidepressant-like activity. The antidepressant-like mechanism of ULEtOH may be related to the increase in monoamines levels in the hippocampus, cortex, striatum, and hypothalamus of mice.
ISSN:1741-427X
1741-4288
DOI:10.1155/2012/497302