Extinction under a behavioral microscope: Isolating the sources of decline in operant response rate

• Published in: Behavioural processes 2012-05, Vol.90 (1), p.111-123
• Main Authors: Cheung, Timothy H.C., Neisewander, Janet L., Sanabria, Federico
• Format: Article
• Language: English
• Subjects: ADHD; Animal ethology; Animals; Bayes Theorem; Biological and medical sciences; Bout; Cocaine - administration & dosage; Cocaine - pharmacology; Conditioning, Operant - drug effects; Data processing; Drug screening; Drug seeking; Drugs; Extinction; Extinction, Psychological - drug effects; Fundamental and applied biological sciences. Psychology; General aspects; Hierarchical model; Learning; Mapping; Memory; Microscopes; Microstructure of behavior; Models, Psychological; Motivation; Operant conditioning; Operant response; physical activity; Psychological Theory; Psychology. Psychoanalysis. Psychiatry; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reinforcement; Reinforcement (Psychology); Reinforcement Schedule; Reinstatement; Self Administration
• ISSN: 0376-6357; 1872-8308
• DOI: 10.1016/j.beproc.2012.02.012

► A novel model separating extinction performance into its behavioral components. ► We illustrate the use of the model with two working examples. ► We describe procedures to identify underlying behavioral processes. ► We describe procedures to estimate model parameters for inferences. ► We provide examples of potential mappings of psychological processes to behavior. Extinction performance is often used to assess underlying psychological processes without the interference of reinforcement. For example, in the extinction/reinstatement paradigm, motivation to seek drug is assessed by measuring responding elicited by drug-associated cues without drug reinforcement. However, extinction performance is governed by several psychological processes that involve motivation, memory, learning, and motoric functions. These processes are confounded when overall response rate is used to measure performance. Based on evidence that operant responding occurs in bouts, this paper proposes an analytic procedure that separates extinction performance into several behavioral components: (1–3) the baseline bout initiation rate, within-bout response rate, and bout length at the onset of extinction; (4–6) their rates of decay during extinction; (7) the time between extinction onset and the decline of responding; (8) the asymptotic response rate at the end of extinction; (9) the refractory period after each response. Data that illustrate the goodness of fit of this analytic model are presented. This paper also describes procedures to isolate behavioral components contributing to extinction performance and make inferences about experimental effects on these components. This microscopic behavioral analysis allows the mapping of different psychological processes to distinct behavioral components implicated in extinction performance, which may further our understanding of the psychological effects of neurobiological treatments.