Morphometric characteristics of basal cell carcinoma peritumoral stroma varies among basal cell carcinoma subtypes

The role that the peritumoral stroma plays in the growth of tumours is currently poorly understood. In this manuscript the morphometric characteristics of basal cell carcinoma subtypes and their associated peritumoral stromas are presented. Ninety eight digitized basal cell carcinoma histology slide...

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Bibliographic Details
Published in:BMC dermatology 2012-03, Vol.12 (1), p.1-1, Article 1
Main Authors: Lesack, Kyle, Naugler, Christopher
Format: Article
Language:English
Subjects:
Angiogenesis
Basal cell carcinoma
Carcinoma, Basal Cell - pathology
Humans
Identification and classification
Measurement
Proteins
Skin Neoplasms - pathology
Smooth muscle
Stromal Cells - pathology
Studies
Wound healing
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Summary:The role that the peritumoral stroma plays in the growth of tumours is currently poorly understood. In this manuscript the morphometric characteristics of basal cell carcinoma subtypes and their associated peritumoral stromas are presented. Ninety eight digitized basal cell carcinoma histology slides were categorized as infiltrative, nodular, or superficial subtypes, and were analysed using a combination of manual and computer-assisted approaches. The morphometric characteristics of the tumour nests and their associated peritumoral stroma were quantified, and the presence of a marked immune reaction or elastosis was noted. The tumour to stroma ratio was different among each tumour subtype. Elastosis was identified in a greater proportion of the infiltrative tumours. Quantitative differences exist between the peritumoral stroma of basal cell carcinoma subtypes. Future work exploring the relation between these morphometric differences and biochemical variations in peritumoral stroma may further our understanding of the biology of carcinoma development. Not applicable.
ISSN:1471-5945
1471-5945
DOI:10.1186/1471-5945-12-1