Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression

Diet and energy metabolism affect gene expression, which influences human health and disease. Here, we discuss the role of epigenetics as a mechanistic link between energy metabolism and control of gene expression. A number of key energy metabolites including SAM, acetyl‐CoA, NAD+, and ATP serve as...

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Bibliographic Details
Published in:Journal of cellular physiology 2012-09, Vol.227 (9), p.3169-3177
Main Authors: Donohoe, Dallas R., Bultman, Scott J.
Format: Article
Language:English
Subjects:
Acetyl Coenzyme A - metabolism
Adenosine Triphosphate - metabolism
Diet
DNA Methylation - genetics
Energy Metabolism
Epigenesis, Genetic - genetics
Gene Expression Regulation
Histones - genetics
Histones - metabolism
Humans
Metabolomics
NAD - metabolism
Protein Processing, Post-Translational - genetics
S-Adenosylmethionine - genetics
S-Adenosylmethionine - metabolism
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Summary:Diet and energy metabolism affect gene expression, which influences human health and disease. Here, we discuss the role of epigenetics as a mechanistic link between energy metabolism and control of gene expression. A number of key energy metabolites including SAM, acetyl‐CoA, NAD+, and ATP serve as essential co‐factors for many, perhaps most, epigenetic enzymes that regulate DNA methylation, posttranslational histone modifications, and nucleosome position. The relative abundance of these energy metabolites allows a cell to sense its energetic state. And as co‐factors, energy metabolites act as rheostats to modulate the activity of epigenetic enzymes and upregulate/downregulate transcription as appropriate to maintain homeostasis. J. Cell. Physiol. 227: 3169–3177, 2012. © 2012 Wiley Periodicals, Inc.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.24054