T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent immunosuppressive cells of the immune system that promote progression of cancer through their ability to limit ant...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2012-05, Vol.72 (9), p.2162-2171
Main Authors: FACCIABENE, Andrea, MOTZ, Gregory T, COUKOS, George
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Antineoplastic agents
Antitumor activity
Biological and medical sciences
Cancer
Cancer vaccines
Humans
Immune response
Immunity
Lymphocytes T
Medical sciences
Neoplasms - blood supply
Neoplasms - immunology
Neoplasms - therapy
Neovascularization, Pathologic - immunology
Neovascularization, Pathologic - therapy
Pharmacology. Drug treatments
T-Lymphocytes, Regulatory - immunology
Tumor Escape - immunology
Tumors
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Summary:T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent immunosuppressive cells of the immune system that promote progression of cancer through their ability to limit antitumor immunity and promote angiogenesis. Here, we discuss the ways in which Tregs suppress the antitumor immune response and elaborate on our recent discovery that Tregs make significant direct contributions to tumor angiogenesis. Further, we highlight several current therapies aimed at eliminating Tregs in cancer patients. Given the multifaceted role of Tregs in cancer, a greater understanding of their functions will ultimately strengthen future therapies.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-11-3687