Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes

A novel family of tetraaza macrocyclic Cu(II) complexes [CuLX2] (where L = N4 donor macrocyclic ligands) and (X = Cl−, NO3−) have been synthesized and characterized by elemental analysis, magnetic moments, IR, EPR, mass, electronic spectra and thermal studies. The magnetic moments and electronic spe...

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Bibliographic Details
Published in:International journal of molecular sciences 2012-04, Vol.13 (4), p.4982-4992
Main Authors: Reddy, Puchakayala Muralidhar, Rohini, Rondla, Krishna, Edulla Ravi, Hu, Anren, Ravinder, Vadde
Format: Article
Language:English
Subjects:
Cefaclor
Chemistry
Copper
Geometry
Gram-negative bacteria
Ligands
Linezolid
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Summary:A novel family of tetraaza macrocyclic Cu(II) complexes [CuLX2] (where L = N4 donor macrocyclic ligands) and (X = Cl−, NO3−) have been synthesized and characterized by elemental analysis, magnetic moments, IR, EPR, mass, electronic spectra and thermal studies. The magnetic moments and electronic spectral studies suggest square planar geometry for [Cu(DBACDT)]Cl2 and [Cu(DBACDT)](NO3)2 complexes and distorted octahedral geometry to the rest of the ten complexes. The biological activity of all these complexes against gram-positive and gram-negative bacteria was compared with the activity of existing commercial antibacterial compounds like Linezolid and Cefaclor. Six complexes out of twelve were found to be most potent against both gram-positive as well as gram-negative bacteria due to the presence of thio group in the coordinated ligands.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms13044982