Exercise and Early-Onset Alzheimer’s Disease: Theoretical Considerations

Background/Aims: Although studies show a negative relationship between physical activity and the risk for cognitive impairment and late-onset Alzheimer’s disease, studies concerning early-onset Alzheimer’s disease (EOAD) are lacking. This review aims to justify the value of exercise interventions in...

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Bibliographic Details
Published in:Dementia and geriatric cognitive disorders extra 2012-04, Vol.2 (1), p.132-145
Main Authors: Hooghiemstra, Astrid M., Eggermont, Laura H.P., Scheltens, Philip, van der Flier, Wiesje M., Scherder, Erik J.A.
Format: Article
Language:English
Subjects:
Dementia
Early-onset Alzheimer’s disease
Early-onset dementia
Intervention
Physical activity
Presenile dementia
Review
Review Article
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Summary:Background/Aims: Although studies show a negative relationship between physical activity and the risk for cognitive impairment and late-onset Alzheimer’s disease, studies concerning early-onset Alzheimer’s disease (EOAD) are lacking. This review aims to justify the value of exercise interventions in EOAD by providing theoretical considerations that include neurobiological processes. Methods: A literature search on key words related to early-onset dementia, exercise, imaging, neurobiological mechanisms, and cognitive reserve was performed. Results/Conclusion: Brain regions and neurobiological processes contributing to the positive effects of exercise are affected in EOAD and, thus, provide theoretical support for exercise interventions in EOAD. Finally, we present the design of a randomized controlled trial currently being conducted in early-onset dementia patients.
ISSN:1664-5464
1664-5464
DOI:10.1159/000335493