Spontaneous retroperitoneal hemorrhage after hemodialysis involving anticoagulant agents

• Published in: Journal of Zhejiang University. B. Science 2012-05, Vol.13 (5), p.408-412
• Main Authors: Fan, Wen-xing, Deng, Zheng-xu, Liu, Fang, Liu, Rong-bo, He, Ling, Amrit, Bogati, Zang, Li, Li, Jing-wen, Liu, Xian-rong, Huang, Song-min, Fu, Ping
• Format: Article
• Language: English
• Subjects: Aged; Anticoagulants - adverse effects; Biomedical and Life Sciences; Biomedicine; Case Report; Diabetic Nephropathies - complications; Diabetic Nephropathies - diagnosis; Female; Hemorrhage - chemically induced; Hemorrhage - diagnosis; Hemorrhage - prevention & control; Humans; Renal Dialysis - adverse effects; Retroperitoneal Space
• ISSN: 1673-1581; 1862-1783
• DOI: 10.1631/jzus.B1100357

In this paper, we described the symptoms and treatment of a patient with diabetic nephropathy accom- panied by spontaneous retroperitoneal hemorrhage after hemodialysis. An elderly female patient with diabetic neph- ropathy presented with severe pain, numbness, and an increasing swelling in the left hip and left thigh after six ses- sions of hemodialysis involving the use of an antiplatelet drug and an anticoagulant agent. Her hemoglobin decreased to 46 g/L. An abdominal ultrasound showed a hematoma in the left retroperitoneal space, and computed tomography （CT） findings revealed a 6 cm×8 cm×10 cm hematoma in the left psoas muscle. After aggressive supportive therapy [the administration of packed red blood cell transfusion, carbazochrome sodium sulfonate injection, and continuous venovenous hemofiltration （CVVH）], the patient＇s vital signs stabilized and her hemoglobin increased to 86 g/L. Repeat CT showed that the hematoma had been partially absorbed after two weeks. Eventually, the patient was discharged with stable vital signs. Physicians should be aware of the possibility of spontaneous retroperitoneal hemorrhage, particularly in patients with diabetic nephropathy undergoing hemodialysis involving the use of anticoagulant agents.