The eIF4F and eIFiso4F Complexes of Plants : An Evolutionary Perspective

Translation initiation in eukaryotes requires a number of initiation factors to recruit the assembled ribosome to mRNA. The eIF4F complex plays a key role in initiation and is a common target point for regulation of protein synthesis. Most work on the translation machinery of plants to date has focu...

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Bibliographic Details
Published in:Comparative and functional genomics 2012-01, Vol.2012 (2012), p.1-12
Main Authors: Patrick, Ryan M., Browning, Karen S.
Format: Article
Language:English
Subjects:
Conserved sequence
Data processing
Evolution
Flowering
Flowers & plants
Genetics
Genomes
Genomics
Initiation factor eIF-4E
Initiation factor eIF-4G
Initiation factors
N-Terminus
Nucleotide sequence
Protein biosynthesis
Proteins
Review
Ribosomes
Translation initiation
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Summary:Translation initiation in eukaryotes requires a number of initiation factors to recruit the assembled ribosome to mRNA. The eIF4F complex plays a key role in initiation and is a common target point for regulation of protein synthesis. Most work on the translation machinery of plants to date has focused on flowering plants, which have both the eIF4F complex (eIF4E and eIF4G) as well as the plant-specific eIFiso4F complex (eIFiso4E and eIFiso4G). The increasing availability of plant genome sequence data has made it possible to trace the evolutionary history of these two complexes in plants, leading to several interesting discoveries. eIFiso4G is conserved throughout plants, while eIFiso4E only appears with the evolution of flowering plants. The eIF4G N-terminus, which has been difficult to annotate, appears to be well conserved throughout the plant lineage and contains two motifs of unknown function. Comparison of eIFiso4G and eIF4G sequence data suggests conserved features unique to eIFiso4G and eIF4G proteins. These findings have answered some questions about the evolutionary history of the two eIF4F complexes of plants, while raising new ones.
ISSN:1531-6912
2314-436X
1532-6268
2314-4378
DOI:10.1155/2012/287814