The Amyloid State of Proteins in Human Diseases

Amyloid fibers and oligomers are associated with a great variety of human diseases including Alzheimer's disease and the prion conditions. Here we attempt to connect recent discoveries on the molecular properties of proteins in the amyloid state with observations about pathological tissues and...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2012-03, Vol.148 (6), p.1188-1203
Main Authors: Eisenberg, David, Jucker, Mathias
Format: Article
Language:English
Subjects:
Alzheimer disease
Alzheimer's disease
Amyloid
Amyloid beta-Protein Precursor - chemistry
Amyloid beta-Protein Precursor - metabolism
Animals
Disease Models, Animal
diseases
Fibers
Gene polymorphism
human diseases
Humans
Models, Molecular
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Nucleation
Plaque, Amyloid - chemistry
Prion protein
prions
Protein Structure, Secondary
Reviews
tissues
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amyloid fibers and oligomers are associated with a great variety of human diseases including Alzheimer's disease and the prion conditions. Here we attempt to connect recent discoveries on the molecular properties of proteins in the amyloid state with observations about pathological tissues and disease states. We summarize studies of structure and nucleation of amyloid and relate these to observations on amyloid polymorphism, prion strains, coaggregation of pathogenic proteins in tissues, and mechanisms of toxicity and transmissibility. Molecular studies have also led to numerous strategies for biological and chemical interventions against amyloid diseases.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.02.022