Mood Response to Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson Disease

Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson disease (PD) improves motor function but has variable effects on mood. Little is known about the relationship between electrode contact location and mood response. We identified the anatomical location of electrode contacts and...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2012-12, Vol.24 (1), p.28-36
Main Authors: Campbell, Meghan C., Black, Kevin J., Weaver, Patrick M., Lugar, Heather M., Videen, Tom O., Tabbal, Samer D., Karimi, Morvarid, Perlmutter, Joel S., Hershey, Tamara
Format: Article
Language:English
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Summary:Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson disease (PD) improves motor function but has variable effects on mood. Little is known about the relationship between electrode contact location and mood response. We identified the anatomical location of electrode contacts and measured mood response to stimulation with the Visual Analog Scale in 24 STN DBS PD patients. Participants reported greater positive mood, decreased anxiety and apathy with bilateral and unilateral stimulation. Left DBS improved mood more than right DBS. Right DBS-induced increase in positive mood was related to more medial and dorsal contact locations. These results highlight the functional heterogeneity of the STN.
ISSN:0895-0172
1545-7222
DOI:10.1176/appi.neuropsych.11030060