Argonaute-2 regulates the proliferation of adult stem cells in planarian

Planarian Schmidtea mediterranea has extraordinary regeneration capabilities due to the abundance of adult stem cells （ASCs） known as neoblasts, which make pla- narian a powerful in vivo system to study ASC biology [ 1 ]. The Argonaute （AGO） family proteins are defined by the presence of Piwi-Argona...

Full description

Saved in:
Bibliographic Details
Published in:Cell research 2011-12, Vol.21 (12), p.1750-1754
Main Authors: Li, Yong-Qin, Zeng, An, Han, Xiao-Shuai, Wang, Chen, Li, Ge, Zhang, Zhen-Chao, Wang, Jian-Yong, Qin, Yong-Wen, Jing, Qing
Format: Article
Language:English
Subjects:
631/136/2091
631/136/532/2118
631/136/532/489
631/45/612/1230
Adult Stem Cells - cytology
Animals
ASCS
Biomedical and Life Sciences
Cell Biology
Cell Proliferation
Helminth Proteins - antagonists & inhibitors
Helminth Proteins - genetics
Helminth Proteins - metabolism
Letter to the Editor
Life Sciences
Planarians - cytology
Planarians - metabolism
Regeneration
RNA Interference
Stem cells
再生能力
成体干细胞
扩散
涡虫
生物调查
蛋白质结合
阿糖胞苷
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Planarian Schmidtea mediterranea has extraordinary regeneration capabilities due to the abundance of adult stem cells （ASCs） known as neoblasts, which make pla- narian a powerful in vivo system to study ASC biology [ 1 ]. The Argonaute （AGO） family proteins are defined by the presence of Piwi-Argonaute-Zwille （PAZ）） and PIWI domains [2], and mediate silencing via cleavage of mR- NAs [3] or inhibition of translation [4]. The AGO family proteins fall into two subfamilies, one named after Ara- bidopsis Argonaute and the other after Drosophila PIWI [5]. In most organisms investigated so far, PIWI proteins bind Piwi-interacting RNAs （piRNAs） and are function- ally involved in the regulation of germ cells [6, 7].
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2011.151