Free Radical Status in Retinopathy of Prematurity

Retinopathy of prematurity (ROP) is a major cause of blindness in children. Free radicals are implicated in the development of this retinopathy. We studied the role of free radicals in ROP and enrolled 60 preterm neonates at 30–32 weeks age. Thirty neonates predisposed to development of ROP, were pl...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2012-04, Vol.27 (2), p.196-199
Main Authors: Garg, Upma, Jain, Anju, Singla, Parul, Beri, Sarita, Garg, Rajiv, Saili, Arvind
Format: Article
Language:English
Subjects:
Antioxidants
Biochemistry
Biomedical and Life Sciences
Blindness
Chemistry/Food Science
Development and progression
Enzymes
Eye diseases
Free radicals
Infants (Premature)
Life Sciences
Microbiology
Original
Original Article
Pathology
Retrolental fibroplasia
Superoxide
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Summary:Retinopathy of prematurity (ROP) is a major cause of blindness in children. Free radicals are implicated in the development of this retinopathy. We studied the role of free radicals in ROP and enrolled 60 preterm neonates at 30–32 weeks age. Thirty neonates predisposed to development of ROP, were placed in study group and 30 normal neonates in control group. Malondialdehyde and antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX) were measured in blood spectrophotometrically. Both the groups were followed-up to 40–42 weeks age. Serum MDA levels, erythrocyte SOD and plasma GPX were significantly high in study group at 30–32 weeks as compared to control group. At follow up visit significant increase in MDA level and decrease in SOD and GPX level among the study group was seen. This disturbance in equilibrium of oxidant and antioxidant status initiates an inflammatory process in retinal tissue leading to development of ROP.
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-011-0180-9