Altered slow wave activity in major depressive disorder with hypersomnia: A high density EEG pilot study

Abstract Hypersomnolence in major depressive disorder (MDD) plays an important role in the natural history of the disorder, but the basis of hypersomnia in MDD is poorly understood. Slow wave activity (SWA) has been associated with sleep homeostasis, as well as sleep restoration and maintenance, and...

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Bibliographic Details
Published in:Psychiatry research. Neuroimaging 2012-03, Vol.201 (3), p.240-244
Main Authors: Plante, David T, Landsness, Eric C, Peterson, Michael J, Goldstein, Michael R, Wanger, Tim, Guokas, Jeff J, Tononi, Giulio, Benca, Ruth M
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Brain - physiopathology
Brain Mapping
Brain Waves - physiology
Depression
Depressive Disorder, Major - complications
Depressive Disorder, Major - pathology
Disorders of Excessive Somnolence - complications
Disorders of Excessive Somnolence - pathology
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
EEG
Electroencephalography
Female
Homeostasis
Humans
Male
Medical sciences
Mood disorders
Nervous system (semeiology, syndromes)
Neuroimaging
Neurology
Pilot Projects
Polysomnography
Psychiatric Status Rating Scales
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Radiology
Sleep
Sleep disorders
Spectral analysis
Statistics
Waves
Young Adult
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Summary:Abstract Hypersomnolence in major depressive disorder (MDD) plays an important role in the natural history of the disorder, but the basis of hypersomnia in MDD is poorly understood. Slow wave activity (SWA) has been associated with sleep homeostasis, as well as sleep restoration and maintenance, and may be altered in MDD. Therefore, we conducted a post-hoc study that utilized high density electroencephalography (hdEEG) to test the hypothesis that MDD subjects with hypersomnia (HYS+) would have decreased SWA relative to age- and sex-matched MDD subjects without hypersomnia (HYS-) and healthy controls ( n = 7 for each group). After correction for multiple comparisons using statistical non-parametric mapping, HYS+ subjects demonstrated significantly reduced parieto-occipital all-night SWA relative to HYS- subjects. Our results suggest hypersomnolence may be associated with topographic reductions in SWA in MDD. Further research using an adequately powered prospective design is indicated to confirm these findings.
ISSN:0925-4927
1872-7506
DOI:10.1016/j.pscychresns.2012.03.001