Detection of methylation of the RAR-β gene in patients with non-small cell lung cancer

The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PC...

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Bibliographic Details
Published in:Oncology letters 2012-03, Vol.3 (3), p.654-658
Main Authors: ZHAO, XUDONG, WANG, NIANFEI, ZHANG, MINGJUN, XUE, SHAOLI, SHI, KAIHU, CHEN, ZHENDONG
Format: Article
Language:English
Subjects:
gene
methylation
non-small cell lung cancer
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Summary:The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PCR; MSP). The results showed that the total frequency of RAR-β methylation was significantly higher in lung cancer tissues compared to the corresponding non-malignant tissues (57.5 vs. 17.5%) (P0.05). A significant difference was observed in the various pathological types (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2011.527