Nucleotide sequences of the penicillin-binding protein 5 and 6 genes of Escherichia coli

Penicillin-binding proteins (PBPs) 5 and 6 are the major D-alaine carboxypeptidases of Escherichia coli . The PBP 5 and PBP 6 genes (dacA and dacC respectively) have been cloned and the nucleotide sequence of a 1597-bp BamHI-EcoRI fragment containing the dacA gene and of a 1505-bp AhaIII-SalI fragme...

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Bibliographic Details
Published in:Nucleic acids research 1988-02, Vol.16 (4), p.1617-1617
Main Authors: BROOME-SMITH, J. K, IOANNIDIS, I, EDELMAN, A, SPRATT, B. G
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Bacterial Proteins
Base Sequence
Biological and medical sciences
Carrier Proteins - genetics
Escherichia coli
Escherichia coli - genetics
Fundamental and applied biological sciences. Psychology
Genes
Genes, Bacterial
Hexosyltransferases
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Muramoylpentapeptide Carboxypeptidase - genetics
Penicillin-Binding Proteins
Penicillins - metabolism
Peptidyl Transferases
Replication
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Description
Summary:Penicillin-binding proteins (PBPs) 5 and 6 are the major D-alaine carboxypeptidases of Escherichia coli . The PBP 5 and PBP 6 genes (dacA and dacC respectively) have been cloned and the nucleotide sequence of a 1597-bp BamHI-EcoRI fragment containing the dacA gene and of a 1505-bp AhaIII-SalI fragment containing the dacC gene are shown. PBP 5 and PBP 6 are cytoplasmic membrane proteins and are synthesised as pre-proteins; the amino-termini of the mature proteins are assigned from published data. PBP 5 and PBP 6 show 62% sequence identity.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/16.4.1617