Polyphenols : Key Issues Involved in Chemoprevention of Prostate Cancer

Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable preneoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compound...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2012-01, Vol.2012 (2012), p.1-8
Main Authors: Cimino, Sebastiano, Sortino, Giuseppe, Favilla, Vincenzo, Castelli, Tommaso, Madonia, Massimo, Sansalone, Salvatore, Russo, Giorgio Ivan, Morgia, Giuseppe
Format: Article
Language:English
Subjects:
Antioxidants - chemistry
Antioxidants - therapeutic use
Catechin - analogs & derivatives
Catechin - chemistry
Catechin - therapeutic use
Curcumin - chemistry
Curcumin - therapeutic use
Flavonoids - chemistry
Flavonoids - therapeutic use
Genistein - chemistry
Genistein - therapeutic use
Humans
Male
Polyphenols - chemistry
Polyphenols - therapeutic use
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - prevention & control
Quercetin - chemistry
Quercetin - therapeutic use
Resveratrol
Review
Stilbenes - chemistry
Stilbenes - therapeutic use
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Summary:Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable preneoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer. This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein. Although the current studies are limited, mechanisms of action of polyphenols added with the lack of side effects show a a start for future strategies in prostate chemoprevention.
ISSN:1942-0900
1942-0994
DOI:10.1155/2012/632959