Progression of renal fibrosis: the underestimated role of endothelial alterations

The vasculature of the kidney is a heterogeneous structure, whose functional integrity is essential for the regulation of renal function. Owing to the importance of the endothelium in vascular biology, chronic endothelial alterations are therefore susceptible to impair multiple aspects of renal phys...

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Bibliographic Details
Published in:Fibrogenesis & tissue repair 2012-06, Vol.5 (Suppl 1), p.S15-S15, Article S15
Main Authors: Guerrot, Dominique, Dussaule, Jean-Claude, Kavvadas, Panagiotis, Boffa, Jean-Jacques, Chadjichristos, Christos E, Chatziantoniou, Christos
Format: Article
Language:English
Subjects:
Disease
Endothelium
Human health and pathology
Hypoxia
Kidney diseases
Life Sciences
Oxidative stress
Proceedings
Proteins
Rodents
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Summary:The vasculature of the kidney is a heterogeneous structure, whose functional integrity is essential for the regulation of renal function. Owing to the importance of the endothelium in vascular biology, chronic endothelial alterations are therefore susceptible to impair multiple aspects of renal physiology and, in turn, to contribute to renal fibrosis. Although systemic endothelial dysfunction is undoubtedly associated with chronic kidney disease, the role of the renal endothelium in the initiation and the progression of renal fibrosis remains largely elusive. In this article, we critically review recent evidence supporting direct and indirect contributions of renal endothelial alterations to fibrosis in the kidney. Specifically, the potential implications of renal endothelial dysfunction and endothelial paucity in parenchymal hypoxia, in the regulation of local inflammation, and in the generation of renal mesenchymal cells are reviewed. We thereafter discuss therapeutic perspectives targeting renal endothelial alterations during the initiation and the progression of renal fibrogenesis.
ISSN:1755-1536
1755-1536
DOI:10.1186/1755-1536-5-s1-s15