The Dynamics of Oral Lichen Planus: A Retrospective Clinicopathological Study

To evaluate disease dynamics, treatment results, and frequency of malignant transformation. Ten-year single center retrospective study. The study included 171 patients, 28–99 years old. Follow-up was 1–16 years. 49.5% exhibited changes in clinical presentation, with 19% yearly increase of probabilit...

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Bibliographic Details
Published in:Head & neck pathology (Totowa, N.J.) N.J.), 2012-06, Vol.6 (2), p.178-183
Main Authors: Kaplan, Ilana, Ventura-Sharabi, Yael, Gal, Gavriel, Calderon, Shlomo, Anavi, Yakir
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents - therapeutic use
Carcinoma, Squamous Cell - epidemiology
Cell Transformation, Neoplastic
Clobetasol - therapeutic use
Dentistry
Dexamethasone - therapeutic use
Female
Humans
Lichen Planus, Oral - classification
Lichen Planus, Oral - drug therapy
Lichen Planus, Oral - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Mouth Neoplasms - epidemiology
Oral and Maxillofacial Surgery
Original Paper
Otorhinolaryngology
Pathology
Precancerous Conditions - classification
Precancerous Conditions - diagnosis
Precancerous Conditions - therapy
Prednisone - therapeutic use
Prevalence
Retrospective Studies
Tacrolimus - therapeutic use
Tretinoin - therapeutic use
Triamcinolone - therapeutic use
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Summary:To evaluate disease dynamics, treatment results, and frequency of malignant transformation. Ten-year single center retrospective study. The study included 171 patients, 28–99 years old. Follow-up was 1–16 years. 49.5% exhibited changes in clinical presentation, with 19% yearly increase of probability for type shift. Index of extent (number of oral locations) showed a mean 40% decrease and 94.1% reported improvement. There were significant differences between treated and untreated patients ( P  = 0.012). Patients with or without systemic diseases had identical treatment requirements for oral lesions. The prevalence of SCC was 5.8%. Oral lichen planus constantly changes presentation and extent of involvement. The effect of systemic diseases was insignificant in the present study. There is a clear value for treatment to reduce the extent of lesions. The results indicate that all clinical forms of the disease need to be equally followed since the clinical presentation typically changes over time, while malignant transformation can occur in all forms.
ISSN:1936-055X
1936-0568
DOI:10.1007/s12105-011-0318-3