The pharmacogenetics of the response to warfarin in Chinese

Warfarin is a commonly used oral anticoagulant with a narrow therapeutic range and large interindividual variability in daily dose. Compared with Caucasians, Chinese are known to require lower doses of warfarin. Differences between Caucasians and Chinese in the allelic frequencies of two genes, CYP2...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2012-03, Vol.73 (3), p.340-347
Main Authors: Lam, May P. S., Cheung, Bernard M. Y.
Format: Article
Language:English
Subjects:
algorithm
Algorithms
Anticoagulants - administration & dosage
Aryl Hydrocarbon Hydroxylases - genetics
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Chinese
CYP2C9 gene
Cytochrome P-450 CYP2C9
Dose-Response Relationship, Drug
European Continental Ancestry Group - genetics
Humans
Medical sciences
Mixed Function Oxygenases - genetics
Pharmacogenetics
Pharmacology. Drug treatments
Polymorphism, Genetic
Reviews
Vitamin K Epoxide Reductases
VKORC1 gene
warfarin
Warfarin - administration & dosage
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Summary:Warfarin is a commonly used oral anticoagulant with a narrow therapeutic range and large interindividual variability in daily dose. Compared with Caucasians, Chinese are known to require lower doses of warfarin. Differences between Caucasians and Chinese in the allelic frequencies of two genes, CYP2C9 and VKORC1, largely explain the difference in dose requirement. There are other genetic polymorphisms that may further explain the response to warfarin. The VKORC1 genotype is an important determinant of response to warfarin in Chinese, but some genetic variants found in other ethnic groups that have a large effect on warfarin response and dosing are not commonly found in Chinese. Therefore, it is important to recognize and beware of ethnic differences in the pharmacogenetics of the response to warfarin, especially in the design of algorithms to aid dosing in clinical practice.
ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.2011.04097.x