Cell polarization and cytokinesis in budding yeast

Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for generating cell diversity during development. The budding yeast Saccharomyces cerevisiae reproduces by asymmetric cell division, and has thus served as an attractive model for unraveling the general principl...

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Bibliographic Details
Published in:Genetics (Austin) 2012-06, Vol.191 (2), p.347-387
Main Authors: Bi, Erfei, Park, Hay-Oak
Format: Article
Language:English
Subjects:
Cell Polarity - physiology
Cells
Cytokines
Cytokinesis - physiology
Genetics
Saccharomycetales - physiology
Yeast
YeastBook
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Summary:Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for generating cell diversity during development. The budding yeast Saccharomyces cerevisiae reproduces by asymmetric cell division, and has thus served as an attractive model for unraveling the general principles of eukaryotic cell polarization and cytokinesis. Polarity development requires G-protein signaling, cytoskeletal polarization, and exocytosis, whereas cytokinesis requires concerted actions of a contractile actomyosin ring and targeted membrane deposition. In this chapter, we discuss the mechanics and spatial control of polarity development and cytokinesis, emphasizing the key concepts, mechanisms, and emerging questions in the field.
ISSN:1943-2631
0016-6731
1943-2631
DOI:10.1534/genetics.111.132886