Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?

Local relapse of tumors after radiation therapy remains a challenge in oncology. To devise rational approaches for preventing this relapse, we have to improve our understanding of how new vessels form in previously irradiated tumors. We propose that tumor regrowth after local irradiation is dependen...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2012-06, Vol.104 (12), p.899-905
Main Authors: Kozin, Sergey V, Duda, Dan G, Munn, Lance L, Jain, Rakesh K
Format: Article
Language:English
Subjects:
Animals
Bone marrow
Endothelial Cells - radiation effects
Humans
Models, Cardiovascular
Neoplasm Recurrence, Local
Neoplasms - blood supply
Neoplasms - radiotherapy
Neovascularization, Pathologic - etiology
Neovascularization, Pathologic - physiopathology
Oncology
Radiation therapy
Time Factors
Tumors
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Summary:Local relapse of tumors after radiation therapy remains a challenge in oncology. To devise rational approaches for preventing this relapse, we have to improve our understanding of how new vessels form in previously irradiated tumors. We propose that tumor regrowth after local irradiation is dependent on blood vessel formation by local endothelial cells without the need for recruitment of endothelial precursor cells from distant nonirradiated tissues or bone marrow. We also suggest that infiltrating myeloid bone marrow-derived cells promote survival of local endothelial cells during the early period after irradiation and angiogenesis during the later stage of tumor regrowth, both via paracrine mechanisms.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/djs239