Transcriptional profiling of vaccine‐induced immune responses in humans and non‐human primates

Summary There is an urgent need for pre‐clinical and clinical biomarkers predictive of vaccine immunogenicity, efficacy and safety to reduce the risks and costs associated with vaccine development. Results emerging from immunoprofiling studies in non‐human primates and humans demonstrate clearly tha...

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Bibliographic Details
Published in:Microbial biotechnology 2012-03, Vol.5 (2), p.177-187
Main Authors: Wang, I‐Ming, Bett, Andrew J., Cristescu, Razvan, Loboda, Andrey, ter Meulen, Jan
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Biomarkers - analysis
Clinical trials
Cytokines
Gene expression
Gene Expression Profiling - methods
Humans
Immune response
Immune system
Immunogenicity
Immunological memory
Infectious diseases
Influenza
Lymphocytes
Lymphocytes B
Measles
Minireviews
Primates
Signal transduction
Stress response
Studies
Transcription
Transcriptome
Tropical diseases
Tuberculosis
Vaccine development
Vaccine efficacy
Vaccines
Vaccines - administration & dosage
Vaccines - immunology
Viruses
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Summary:Summary There is an urgent need for pre‐clinical and clinical biomarkers predictive of vaccine immunogenicity, efficacy and safety to reduce the risks and costs associated with vaccine development. Results emerging from immunoprofiling studies in non‐human primates and humans demonstrate clearly that (i) type and duration of immune memory are largely determined by the magnitude and complexity of the innate immune signals and (ii) genetic signatures highly predictive of B‐cell and T‐cell responses can be identified for specific vaccines. For vaccines with similar composition, e.g. live attenuated viral vaccines, these signatures share common patterns. Signatures predictive of vaccine efficacy have been identified in a few experimental challenge studies. This review aims to give an overview of the current literature on immunoprofiling studies in humans and also presents some of our own data on profiling of licensed and experimental vaccines in non‐human primates.
ISSN:1751-7915
1751-7915
DOI:10.1111/j.1751-7915.2011.00317.x