Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR's

This study emphasizes the dynamical properties of mechanical loading via simulated microgravity, its effect on acute myeloid leukemia proliferation and hematopoietic stem cell (HSPC) growth and its implications in the area of tissue regeneration. Data presented illustrates that mechanical transducti...

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Bibliographic Details
Published in:Oncotarget 2012-04, Vol.3 (4), p.426-434
Main Authors: Puca, Andrew, Russo, Giuseppe, Giordano, Antonio
Format: Article
Language:English
Subjects:
Adult
Antigens, CD34 - metabolism
Bone Marrow Cells - cytology
Bone Marrow Cells - metabolism
Cell Proliferation
Cell Survival
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - metabolism
Humans
Intracellular Space
Jurkat Cells
Leukemia - metabolism
Leukemia - pathology
Mechanotransduction, Cellular
Protein Transport
Receptors, Vascular Endothelial Growth Factor - metabolism
Research Papers
Weightlessness Simulation
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Summary:This study emphasizes the dynamical properties of mechanical loading via simulated microgravity, its effect on acute myeloid leukemia proliferation and hematopoietic stem cell (HSPC) growth and its implications in the area of tissue regeneration. Data presented illustrates that mechanical transduction changes the expression of humoral factors by facilitating paracrine/autocrine signalling, therefore modulating intracellular trafficking of tyrosine kinase receptors. Understanding mechano-transduction in the context of cell and tissue morphogenesis is the major focus of this study. The effects of external physiological stresses, such as blood flow, on several cellular subtypes seem to produce very intricate cellular responses. It is well accepted that mechanical loading plays an intrinsic and extrinsic influence on cell survival. This study shows how microgravity effects hematopoietic stem cells, and human leukemic cell proliferation and expression of its receptors that control cell survival, such as the tyrosine kinase vascular endothelial growth factor receptor-1, receptor-2 and receptor-3.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.472