Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source

We developed optical coherence photoacoustic microscopy (OC-PAM) to demonstrate that the functions of optical coherence tomography (OCT) and photoacoustic microscopy (PAM) can be achieved simultaneously by using a single illuminating light source. We used a pulsed broadband laser centered at 580 nm...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2012-03, Vol.17 (3), p.030502-030503
Main Authors: Zhang, Xiangyang, Zhang, Hao F, Jiao, Shuliang
Format: Article
Language:English
Subjects:
Absorption
Animals
Broadband
Coherence
Ear - blood supply
Equipment Design
hemoglobin
Interferometers
Interferometry
JBO Letters
Lasers
Light sources
melanin
Mice
Microscopy - instrumentation
Microscopy - methods
Optical Coherence Tomography
photoacoustic image
Photoacoustic microscopy
Photoacoustic Techniques - instrumentation
Photoacoustic Techniques - methods
Photons
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - methods
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Summary:We developed optical coherence photoacoustic microscopy (OC-PAM) to demonstrate that the functions of optical coherence tomography (OCT) and photoacoustic microscopy (PAM) can be achieved simultaneously by using a single illuminating light source. We used a pulsed broadband laser centered at 580 nm and detected the absorbed photons through photoacoustic detection and the back-scattered photons with an interferometer. In OC-PAM, each laser pulse generates both one OCT A-line and one PAM A-line simultaneously; as a result, the two imaging modalities are intrinsically co-registered in the lateral directions. images of the mouse ear were acquired to demonstrate the capabilities of OC-PAM.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.17.3.030502