Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial

Abstract This study further evaluates the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). A diagnostically heterogeneous clinical sample of 37 patients with a principal anxiety disorder diagnosis was enrolled in a randomized controlled trial (RCT) involvin...

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Bibliographic Details
Published in:Behavior therapy 2012-09, Vol.43 (3), p.666-678
Main Authors: Farchione, Todd J, Fairholme, Christopher P, Ellard, Kristen K, Boisseau, Christina L, Thompson-Hollands, Johanna, Carl, Jenna R, Gallagher, Matthew W, Barlow, David H
Format: Article
Language:English
Subjects:
Adult
Anxiety
anxiety disorders
Anxiety Disorders - complications
Anxiety Disorders - therapy
Anxiety-Depression
Behavior therapy. Cognitive therapy
Biological and medical sciences
Clinical trials
Cognitive Behavioral Therapy - methods
Cognitive Behavioral Therapy - statistics & numerical data
cognitive-behavioral treatment
Comorbidity
Depressive Disorder - complications
Depressive Disorder - therapy
Efficacy
Emotional disorders
Female
Humans
Male
Medical diagnosis
Medical sciences
Mental depression
Middle Aged
Psychiatric Status Rating Scales - statistics & numerical data
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Randomized controlled trials
Symptoms
transdiagnostic
Treatments
unified protocol
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Summary:Abstract This study further evaluates the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). A diagnostically heterogeneous clinical sample of 37 patients with a principal anxiety disorder diagnosis was enrolled in a randomized controlled trial (RCT) involving up to 18 sessions of treatment and a 6-month follow-up period. Patients were randomly assigned to receive either immediate treatment with the UP ( n = 26) or delayed treatment, following a 16-week wait-list control period (WLC; n = 11). The UP resulted in significant improvement on measures of clinical severity, general symptoms of depression and anxiety, levels of negative and positive affect, and a measure of symptom interference in daily functioning across diagnoses. In comparison, participants in the WLC condition exhibited little to no change following the 16-week wait-list period. The effects of UP treatment were maintained over the 6-month follow-up period. Results from this RCT provide additional evidence for the efficacy of the UP in the treatment of anxiety and comorbid depressive disorders, and provide additional support for a transdiagnostic approach to the treatment of emotional disorders.
ISSN:0005-7894
1878-1888
DOI:10.1016/j.beth.2012.01.001