Adjuvants for human vaccines

Highlights ► Formulations of adjuvants can have different properties than individual adjuvants. ► Beneficial adjuvant formulations can be made with alum, oil emulsions, and liposomes. ► Effectiveness, safety, stability, and cost are important features of formulations. ► Nonhuman primates are often m...

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Bibliographic Details
Published in:Current opinion in immunology 2012-06, Vol.24 (3), p.310-315
Main Authors: Alving, Carl R, Peachman, Kristina K, Rao, Mangala, Reed, Steven G
Format: Article
Language:English
Subjects:
Adjuvants
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - chemistry
Allergy and Immunology
Aluminum
Animals
Dosage Forms
Humans
Immunization
Lipids
Liposomes
Microinjection
Monophosphoryl lipid A
Oil
Pattern recognition
Primates
Reviews
Salts
Signal Transduction
Skin
TLR4 protein
Toll-like receptors
Toll-Like Receptors - immunology
Vaccines
Vaccines - immunology
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Summary:Highlights ► Formulations of adjuvants can have different properties than individual adjuvants. ► Beneficial adjuvant formulations can be made with alum, oil emulsions, and liposomes. ► Effectiveness, safety, stability, and cost are important features of formulations. ► Nonhuman primates are often more predictive than rodents for human adjuvant effects. ► Numerous adjuvants, materials, devices, and strategies are useful for skin immunization.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2012.03.008