The C-terminus of neuronal Kv2.1 channels is required for channel localization and targeting but not for NMDA-receptor-mediated regulation of channel function

Highlights ► Localization of Kv2.1 and Kv2.2 is governed by a common mechanism. ► Both NR2a- and NR2b-containing NMDA receptors modulate Kv2.1. ► The Kv2.2 C-terminus disrupts Kv2.1 clustering but not Kv2.1 gating. ► The C-terminus is required for clustering but not for gating or modulation of Kv2.1...

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Bibliographic Details
Published in:Neuroscience 2012-08, Vol.217, p.56-66
Main Authors: Baver, S.B, O’Connell, K.M.S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
C-Terminus
Cells, Cultured
Channel gating
delayed rectifier
Excitability
Fundamental and applied biological sciences. Psychology
gating
HEK293 Cells
Hippocampus
Hippocampus - cytology
Hippocampus - metabolism
Humans
Ion Channel Gating - physiology
Kv2 channels
Kv2.1 clustering
Membrane Potentials - physiology
N-Methyl-D-aspartic acid
Nervous system
Neurology
Neurons
Neurons - cytology
Neurons - metabolism
Potassium channels (voltage-gated)
quantum dot
Rats
Receptors, N-Methyl-D-Aspartate - metabolism
Shab Potassium Channels - metabolism
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Localization of Kv2.1 and Kv2.2 is governed by a common mechanism. ► Both NR2a- and NR2b-containing NMDA receptors modulate Kv2.1. ► The Kv2.2 C-terminus disrupts Kv2.1 clustering but not Kv2.1 gating. ► The C-terminus is required for clustering but not for gating or modulation of Kv2.1.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.04.054