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The C-terminus of neuronal Kv2.1 channels is required for channel localization and targeting but not for NMDA-receptor-mediated regulation of channel function
Highlights ► Localization of Kv2.1 and Kv2.2 is governed by a common mechanism. ► Both NR2a- and NR2b-containing NMDA receptors modulate Kv2.1. ► The Kv2.2 C-terminus disrupts Kv2.1 clustering but not Kv2.1 gating. ► The C-terminus is required for clustering but not for gating or modulation of Kv2.1...
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| Published in: | Neuroscience 2012-08, Vol.217, p.56-66 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c605t-c1adae5d7d44aceae887cdc5cd059dbb129d997c12eff1c364fb60b4da8597f93 |
| container_end_page | 66 |
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| container_start_page | 56 |
| container_title | Neuroscience |
| container_volume | 217 |
| creator | Baver, S.B O’Connell, K.M.S |
| description | Highlights ► Localization of Kv2.1 and Kv2.2 is governed by a common mechanism. ► Both NR2a- and NR2b-containing NMDA receptors modulate Kv2.1. ► The Kv2.2 C-terminus disrupts Kv2.1 clustering but not Kv2.1 gating. ► The C-terminus is required for clustering but not for gating or modulation of Kv2.1. |
| doi_str_mv | 10.1016/j.neuroscience.2012.04.054 |
| format | article |
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| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2012-08, Vol.217, p.56-66 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3383376 |
| source | ScienceDirect Freedom Collection |
| subjects | Animals Biological and medical sciences C-Terminus Cells, Cultured Channel gating delayed rectifier Excitability Fundamental and applied biological sciences. Psychology gating HEK293 Cells Hippocampus Hippocampus - cytology Hippocampus - metabolism Humans Ion Channel Gating - physiology Kv2 channels Kv2.1 clustering Membrane Potentials - physiology N-Methyl-D-aspartic acid Nervous system Neurology Neurons Neurons - cytology Neurons - metabolism Potassium channels (voltage-gated) quantum dot Rats Receptors, N-Methyl-D-Aspartate - metabolism Shab Potassium Channels - metabolism Vertebrates: nervous system and sense organs |
| title | The C-terminus of neuronal Kv2.1 channels is required for channel localization and targeting but not for NMDA-receptor-mediated regulation of channel function |
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