Bazedoxifene: the evolving role of third-generation selective estrogen-receptor modulators in the management of postmenopausal osteoporosis

Osteoporosis is a significant public health concern, particularly for postmenopausal women. Current treatment options may not be appropriate for all women. Selective estrogen-receptor modulators (SERMs) are a class of molecules with tissue-selective activity. Bazedoxifene is currently in clinical de...

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Bibliographic Details
Published in:Therapeutic advances in musculoskeletal disease 2012-02, Vol.4 (1), p.21-34
Main Authors: Komm, Barry S., Chines, Arkadi A.
Format: Article
Language:English
Subjects:
Biochemical markers
Bisphosphonates
Bone mineral density
Bone turnover
Clinical trials
Endometrium
Estrogen receptors
Fractures
Health risk assessment
Hormone replacement therapy
Osteoporosis
Post-menopause
Public health
Raloxifene
Reviews
Risk assessment
Risk factors
selective estrogen receptor modulators
Thrombosis
Veins
Vertebrae
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Summary:Osteoporosis is a significant public health concern, particularly for postmenopausal women. Current treatment options may not be appropriate for all women. Selective estrogen-receptor modulators (SERMs) are a class of molecules with tissue-selective activity. Bazedoxifene is currently in clinical development for the prevention and treatment of postmenopausal osteoporosis. In a 2-year, phase III, osteoporosis prevention study (N = 1583), bazedoxifene 10, 20, and 40 mg was shown to preserve bone mineral density and decrease biochemical markers of bone turnover compared with placebo in postmenopausal women at risk for osteoporosis. In a pivotal 3-year, phase III, osteoporosis treatment study (N = 7492), bazedoxifene 20 and 40 mg significantly reduced the incidence of new vertebral fractures compared with placebo (p 
ISSN:1759-720X
1759-7218
DOI:10.1177/1759720X11422602