Pt-Catalyzed Cyclization/1,2-Migration for the Synthesis of Indolizines, Pyrrolones, and Indolizinones

Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily...

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Bibliographic Details
Published in:Organic letters 2007-03, Vol.9 (6), p.1169-1171
Main Authors: Smith, Cameron R, Bunnelle, Eric M, Rhodes, Allison J, Sarpong, Richmond
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Catalysis
Cyclization
Heterocyclic Compounds - chemical synthesis
Indolizines - chemical synthesis
Isomerism
Models, Chemical
Platinum - chemistry
Propanols - chemistry
Pyridines - chemistry
Pyrroles - chemical synthesis
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Summary:Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily available substrates.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0701971