Pt-Catalyzed Cyclization/1,2-Migration for the Synthesis of Indolizines, Pyrrolones, and Indolizinones

Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily...

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Published in:Organic letters 2007-03, Vol.9 (6), p.1169-1171
Main Authors: Smith, Cameron R, Bunnelle, Eric M, Rhodes, Allison J, Sarpong, Richmond
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Catalysis
Cyclization
Heterocyclic Compounds - chemical synthesis
Indolizines - chemical synthesis
Isomerism
Models, Chemical
Platinum - chemistry
Propanols - chemistry
Pyridines - chemistry
Pyrroles - chemical synthesis
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cited_by cdi_FETCH-LOGICAL-a469t-abda1061273c8977bc715bbba1d979e9beffc0b5bdd5650b150c6c188770d383
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creator Smith, Cameron R
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description Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily available substrates.
doi_str_mv 10.1021/ol0701971
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Alkynes - chemistry
Catalysis
Cyclization
Heterocyclic Compounds - chemical synthesis
Indolizines - chemical synthesis
Isomerism
Models, Chemical
Platinum - chemistry
Propanols - chemistry
Pyridines - chemistry
Pyrroles - chemical synthesis
title Pt-Catalyzed Cyclization/1,2-Migration for the Synthesis of Indolizines, Pyrrolones, and Indolizinones
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