Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin‐17 secreting cell in renal allograft biopsies with acute T‐cell‐mediated rejection

• Published in: Immunology 2012-07, Vol.136 (3), p.344-351
• Main Authors: Chung, Byung H., Oh, Hye J., Piao, Shang G., Hwang, Hyeon S., Sun, In O., Choi, Sun R., Park, Hoon S., Choi, Bum S., Choi, Yeong J., Park, Cheol W., Kim, Yong‐Soo, Cho, Mi‐La, Yang, Chul W.
• Format: Article
• Language: English
• Subjects: Acute Disease; acute T‐cell‐mediated rejection; Adult; Female; Forkhead Transcription Factors - metabolism; FOXP3; Graft Rejection - etiology; Graft Rejection - immunology; Graft Rejection - pathology; Graft Survival - immunology; Humans; Immunohistochemistry; Interleukin-17 - biosynthesis; interleukin‐17; Kidney Transplantation - adverse effects; Kidney Transplantation - immunology; Kidney Transplantation - pathology; Male; Middle Aged; Original; Prognosis; regulatory T cell; Retrospective Studies; T helper type 17; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; T-Lymphocytes, Regulatory - pathology; Th17 Cells - immunology
• ISSN: 0019-2805; 1365-2567
• DOI: 10.1111/j.1365-2567.2012.03588.x

Summary The aim of this study is to investigate the clinical significance of the ratio between interleukin‐17 (IL‐17) secreting cell and FOXP3‐positive regulatory T cell (FOXP3+ Treg) infiltration in renal allograft tissues with acute T‐cell‐mediated rejection (ATCMR). Fifty‐six patients with biopsy‐proven ATCMR were included. Infiltration of FOXP3+ Treg and IL‐17‐secreting cells was evaluated with immunostaining for FOXP3 or IL‐17 on the biopsy specimens, and the patients were divided into the FOXP3 high group (Log FOXP3/IL‐17 > 0·45) or the IL‐17 high group (Log FOXP3/IL‐17