Association of Polymorphisms in Mitofusin-2 Gene with Type 2 Diabetes in Han Chinese

MFN2 and ESRRA are candidate genes involved in the pathogenesis of T2D. Five tag-SNPs in MFN2 gene and three in ESRRA gene were selected and genotyped with TaqMan or PCR-RFLP method in stage 1 populations (555 patients with T2D and 649 control subjects) and stage 2 populations (546 patients with T2D...

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Bibliographic Details
Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-7
Main Authors: Niu, Fenghe, Wu, Jia, Liu, Ying, Li, Pengtao, Xin, Zhenhui, Pan, Liping, Li, Jingyun, Zhu, Shuying, Wu, Xiaopan, Zhu, Xilin
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Asian People - genetics
Biomedical research
Blood pressure
Case-Control Studies
China - epidemiology
Deoxyribonucleic acid
Diabetes
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - genetics
DNA
ERRalpha Estrogen-Related Receptor
Female
Gene expression
Genetic Predisposition to Disease
Genotype
GTP Phosphohydrolases - genetics
Haplotypes
Humans
Insulin resistance
Linkage Disequilibrium
Male
Middle Aged
Mitochondrial Proteins - genetics
Musculoskeletal system
Pathogenesis
Polymorphism, Single Nucleotide
Proteins
Receptors, Estrogen - genetics
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Summary:MFN2 and ESRRA are candidate genes involved in the pathogenesis of T2D. Five tag-SNPs in MFN2 gene and three in ESRRA gene were selected and genotyped with TaqMan or PCR-RFLP method in stage 1 populations (555 patients with T2D and 649 control subjects) and stage 2 populations (546 patients with T2D versus 419 control subjects) in Han Chinese. And combining our published data, we estimated the interactions between genetic variants in the MFN2, ESRRA, and PGC-1α genes on the T2D risk using MDR. rs873458 (G>A) and rs2878677 (C>T) in MFN2 gene were significantly associated with T2D (P=0.005 and 0.01) in stage 1 populations, and the association of other SNPs with T2D was not found. In stage 2 populations, we further confirmed the association between rs2878677 and T2D (P=0.01). Combining the two stage populations, the data supported more significant effect of rs873458 and rs2878677 on T2D risk (P=0.003 and 0.0001). A-C-G-T-C and G-T-C-T-C in MFN2 had significant association with T2D (P=0.007 and 0.009). The present study also provided the evidence that MFN2 had interactions with PGC-1α (P
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2012/205752