Codon usage in Pseudomonas aeruginosa

We have generated a codon usage table for Pseudomonas aeruginosa. Codon usage in P. aeruginosa is extremely biased. In contrast to E. coli and yeast, P. aeruginosa preferentially uses those codons within a synonymous codon group with the strongest predicted codon-anticodon interaction. We were unabl...

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Bibliographic Details
Published in:Nucleic acids research 1988-10, Vol.16 (19), p.9323-9335
Main Authors: WEST, S. E. H, IGLEWSKI, B. H
Format: Article
Language:English
Subjects:
Bacteriophages - genetics
Biological and medical sciences
Chromosomes, Bacterial
Codon
DNA Transposable Elements
Escherichia coli
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes
Genes, Bacterial
Genetic code
Molecular and cellular biology
Molecular genetics
Plasmids
Pseudomonas aeruginosa
Pseudomonas aeruginosa - genetics
RNA, Messenger - genetics
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Summary:We have generated a codon usage table for Pseudomonas aeruginosa. Codon usage in P. aeruginosa is extremely biased. In contrast to E. coli and yeast, P. aeruginosa preferentially uses those codons within a synonymous codon group with the strongest predicted codon-anticodon interaction. We were unable to correlate a particular codon usage pattern with predicted levels of mRNA expressivity. The choice of a third base reflects the high guanine plus cytosine content of the P. aeruginosa genome (67.2%) and cytosine is the preferred nucleotide for the third codon position.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/16.19.9323