Endothelin: Key Mediator of Hypertension in Preeclampsia

Preeclampsia is a pregnancy-induced hypertensive disorder characterized by proteinuria and widespread maternal endothelial dysfunction. It remains one of the most common disorders in pregnancy and remains one of the leading causes of maternal and fetal morbidity. Recent research has revealed that pl...

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Bibliographic Details
Published in:American journal of hypertension 2011-09, Vol.24 (9), p.964-969
Main Authors: George, Eric M, Granger, Joey P
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Autoantibodies - metabolism
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Endothelin A Receptor Antagonists
Endothelin-1 - physiology
Female
Humans
Hypertension, Pregnancy-Induced - metabolism
Medical sciences
Pre-Eclampsia - etiology
Pre-Eclampsia - physiopathology
Pre-Eclampsia - therapy
Pregnancy
Receptor, Angiotensin, Type 1 - immunology
Vascular Endothelial Growth Factor Receptor-1 - metabolism
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Summary:Preeclampsia is a pregnancy-induced hypertensive disorder characterized by proteinuria and widespread maternal endothelial dysfunction. It remains one of the most common disorders in pregnancy and remains one of the leading causes of maternal and fetal morbidity. Recent research has revealed that placental insufficiency, resulting in hypoxia and ischemia, is a central causative pathway in the development of the disorder. In response, the placenta secretes soluble substances into the maternal circulation which are responsible for the symptomatic phase of the disease. Among the most well characterized factors in the disease pathology are the anti-angiogenic protein soluble fms-like tyrosine kinase-1 (sFlt-1), inflammatory cytokines, and agonistic angiotensin II type-1 receptor autoantibodies. Each of these factors has been shown to induce hypertension experimentally through the production of endothelin-1 (ET-1), a powerful vasoconstrictor. Antagonism of the endothelin-A receptor has proved beneficial in numerous animal models of gestational hypertension, and it remains an intriguing target for pharmacological intervention in preeclampsia. American Journal of Hypertension advance online publication 16 June 2011;doi:10.1038/ajh.2011.99
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1038/ajh.2011.99