Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma

• Published in: Oncology letters 2012-05, Vol.3 (5), p.990-994
• Main Authors: KUBOTA, KEI, TAMURA, TAIJI, AOYAMA, NOBUTAKA, NOGAMI, MUNENOBU, HAMADA, NORIHIKO, NISHIOKA, AKIHITO, OGAWA, YASUHIRO
• Format: Article
• Language: English
• Subjects: contrast material; gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid; hepatocellular carcinoma; liver function; magnetic resonance imaging
• ISSN: 1792-1074; 1792-1082
• DOI: 10.3892/ol.2012.629

Animal studies have demonstrated that liver function parameters affect the degree of liver enhancement by gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA). The present study prospectively investigated whether liver function parameters and liver damage scores similarly correlate with the degree of liver enhancement by Gd-EOB-DTPA in humans with hepatocellular carcinoma (HCC). A total of 41 patients (32 males, 9 females; mean age, 71.9 years; range, 38-86 years) with suspected HCC provided written, informed consent to undergo a Gd-EOB-DTPA (30 μmol/kg of body weight)-enhanced T1-gradient-echo (GRE) magnetic resonance imaging (MRI) study. The signal intensity of the liver parenchyma was quantified at various time points following injection of Gd-EOB-DTPA. We investigated the correlations between maximal relative enhancement (RE) values and liver function parameters, and liver damage scores. Correlations between parameters and maximum RE values were determined using the Student's t-test and univariate regression analyses. The effect of potential confounding factors was controlled by multiple stepwise regression analysis. Two-tailed values of p