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Ontogeny of Cardiac Sympathetic Innervation and Its Implications for Cardiac Disease
The vertebrate heart is innervated by the sympathetic and parasympathetic components of the peripheral autonomic nervous system, which regulates its contractile rate and force. Understanding the mechanisms that control sympathetic neuronal growth, differentiation, and innervation of the heart may pr...
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| Published in: | Pediatric cardiology 2012-08, Vol.33 (6), p.923-928 |
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| Main Authors: | , , |
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| Language: | English |
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| container_end_page | 928 |
| container_issue | 6 |
| container_start_page | 923 |
| container_title | Pediatric cardiology |
| container_volume | 33 |
| creator | Vincentz, Joshua W. Rubart, Michael Firulli, Anthony B. |
| description | The vertebrate heart is innervated by the sympathetic and parasympathetic components of the peripheral autonomic nervous system, which regulates its contractile rate and force. Understanding the mechanisms that control sympathetic neuronal growth, differentiation, and innervation of the heart may provide insight into the etiology of cardiac arrhythmogenesis. This review provides an overview of the cell signaling pathways and transcriptional effectors that regulate both the noradrenergic gene program during sympathetic neurogenesis and regional nerve density during cardiac innervation. Recent studies exploring transcriptional regulation of the bHLH transcription factor Hand1 in developing sympathetic neurons are explored, and how the
Hand1
sympathetic neuron-specific
cis
-regulatory element may be used further to assess the contribution of altered sympathetic innervation to human cardiac disease is discussed. |
| doi_str_mv | 10.1007/s00246-012-0248-1 |
| format | article |
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Hand1
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Hand1
sympathetic neuron-specific
cis
-regulatory element may be used further to assess the contribution of altered sympathetic innervation to human cardiac disease is discussed.</description><subject>Arrhythmia</subject><subject>Basic Helix-Loop-Helix Transcription Factors - genetics</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cell Differentiation</subject><subject>Cellular signal transduction</subject><subject>Development and progression</subject><subject>Gene Expression Regulation</subject><subject>Genetic transcription</subject><subject>Heart - innervation</subject><subject>Heart Diseases - etiology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurogenesis</subject><subject>Neurons</subject><subject>Riley Symposium</subject><subject>Signal Transduction</subject><subject>Sympathetic Nervous System - anatomy & histology</subject><subject>Sympathetic Nervous System - growth & development</subject><subject>Sympathetic Nervous System - metabolism</subject><subject>Vascular Surgery</subject><issn>0172-0643</issn><issn>1432-1971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kc1q3DAUhUVpaaZpH6CbYuimG6dXliXbm0KY_g0Esmi6Fteaq4mCLU0lT2DePnKdDg2UooXEPd85SDqMveVwwQGajwmgqlUJvCrzoS35M7bitahK3jX8OVsBb7KianHGXqV0BwAttPIlO6sq0UklYcVurv0UduSPRbDFGuPWoSl-HMc9Trc0OVNsvKd4j5MLvkC_LTZTKjbjfnDm9ywVNsST8bNLhIlesxcWh0RvHvdz9vPrl5v19_Lq-ttmfXlVGgndVHZKEXXKIvR9ayTWqpXGtg2arjWdtWBREaBpemsF9VYZLtotyqpGMEpIcc4-Lbn7Qz_S1pCfIg56H92I8agDOv1U8e5W78K9FqLjQs4BHx4DYvh1oDTp0SVDw4CewiFpnr-1bjqQTUbfL-gOB9LO25ATzYzry4ZLWVUKZuriH1ReWxqdCZ6sy_MnBr4YTAwpRbKn23PQc8l6KVnnkvVcsubZ8-7vZ58cf1rNQLUAKUt-R1HfhUP0uYr_pD4A5a-yuA</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Vincentz, Joshua W.</creator><creator>Rubart, Michael</creator><creator>Firulli, Anthony B.</creator><general>Springer-Verlag</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120801</creationdate><title>Ontogeny of Cardiac Sympathetic Innervation and Its Implications for Cardiac Disease</title><author>Vincentz, Joshua W. ; 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Understanding the mechanisms that control sympathetic neuronal growth, differentiation, and innervation of the heart may provide insight into the etiology of cardiac arrhythmogenesis. This review provides an overview of the cell signaling pathways and transcriptional effectors that regulate both the noradrenergic gene program during sympathetic neurogenesis and regional nerve density during cardiac innervation. Recent studies exploring transcriptional regulation of the bHLH transcription factor Hand1 in developing sympathetic neurons are explored, and how the
Hand1
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cis
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| fulltext | fulltext |
| identifier | ISSN: 0172-0643 |
| ispartof | Pediatric cardiology, 2012-08, Vol.33 (6), p.923-928 |
| issn | 0172-0643 1432-1971 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3391355 |
| source | Springer Nature |
| subjects | Arrhythmia Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Cardiac Surgery Cardiology Cell Differentiation Cellular signal transduction Development and progression Gene Expression Regulation Genetic transcription Heart - innervation Heart Diseases - etiology Humans Medicine Medicine & Public Health Neurogenesis Neurons Riley Symposium Signal Transduction Sympathetic Nervous System - anatomy & histology Sympathetic Nervous System - growth & development Sympathetic Nervous System - metabolism Vascular Surgery |
| title | Ontogeny of Cardiac Sympathetic Innervation and Its Implications for Cardiac Disease |
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