Abnormal Segregation of Alleles and Haplotypes at the Polymorphic Site of the PRNP Gene Within Promoter and Intron 1 Regions in Polish Holstein–Friesian Cattle

Allele and haplotype segregation at the polymorphic sites within the promoter (23indel) and intron 1 (12indel) regions of the PRNP gene was analyzed in Polish Holstein–Friesian cattle. More 23del/del homozygotes and fewer 23ins/ins homozygotes than expected were observed in the offspring of ♂ 23ins/...

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Bibliographic Details
Published in:Biochemical genetics 2012-08, Vol.50 (7-8), p.520-528
Main Authors: Strychalski, Janusz, Czarnik, Urszula, Zabolewicz, Tadeusz
Format: Article
Language:English
Subjects:
Alleles
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cattle
Cattle - genetics
Gene Frequency - genetics
Genotypes
Haplotypes
Haplotypes - genetics
homozygosity
Homozygotes
Human Genetics
Inheritance Patterns - genetics
Introns
Introns - genetics
Medical Microbiology
Offspring
parents
Polymorphism, Genetic - genetics
Prion protein
Prions - genetics
Progeny
Promoter Regions, Genetic - genetics
Promoters
Zoology
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Summary:Allele and haplotype segregation at the polymorphic sites within the promoter (23indel) and intron 1 (12indel) regions of the PRNP gene was analyzed in Polish Holstein–Friesian cattle. More 23del/del homozygotes and fewer 23ins/ins homozygotes than expected were observed in the offspring of ♂ 23ins/del × ♀ 23ins/del parents. In the offspring of ♂ 23ins/del × ♀ 23del/del parents and ♂ 23del/del × ♀ 23ins/del parents, a trend toward more 23del/del animals and fewer 23ins/del animals than expected was noted. At the 12indel polymorphic site, the only trend found was one toward fewer 12ins/ins genotypes and more 12ins/del and 12del/del genotypes than expected in the offspring of ♂ 12ins/del × ♀ 12ins/del parents. An analysis of haplotype segregation revealed more 23del-12del/23del-12del diplotypes and fewer 23ins-12ins/23ins-12ins diplotypes at the significance threshold than expected in the offspring of ♂ 23ins-12ins/23del-12del × ♀ 23ins-12ins/23del-12del parents.
ISSN:0006-2928
1573-4927
DOI:10.1007/s10528-012-9496-2