Immune epitope database analysis resource

The immune epitope database analysis resource (IEDB-AR: http://tools.iedb.org) is a collection of tools for prediction and analysis of molecular targets of T- and B-cell immune responses (i.e. epitopes). Since its last publication in the NAR webserver issue in 2008, a new generation of peptide:MHC b...

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Bibliographic Details
Published in:Nucleic acids research 2012-07, Vol.40 (Web Server issue), p.W525-W530
Main Authors: Kim, Yohan, Ponomarenko, Julia, Zhu, Zhanyang, Tamang, Dorjee, Wang, Peng, Greenbaum, Jason, Lundegaard, Claus, Sette, Alessandro, Lund, Ole, Bourne, Philip E, Nielsen, Morten, Peters, Bjoern
Format: Article
Language:English
Subjects:
Epitopes, B-Lymphocyte - chemistry
Epitopes, T-Lymphocyte - chemistry
Histocompatibility Antigens Class I - metabolism
Histocompatibility Antigens Class II - metabolism
Humans
Internet
Peptides - immunology
Software
Structural Homology, Protein
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Description
Summary:The immune epitope database analysis resource (IEDB-AR: http://tools.iedb.org) is a collection of tools for prediction and analysis of molecular targets of T- and B-cell immune responses (i.e. epitopes). Since its last publication in the NAR webserver issue in 2008, a new generation of peptide:MHC binding and T-cell epitope predictive tools have been added. As validated by different labs and in the first international competition for predicting peptide:MHC-I binding, their predictive performances have improved considerably. In addition, a new B-cell epitope prediction tool was added, and the homology mapping tool was updated to enable mapping of discontinuous epitopes onto 3D structures. Furthermore, to serve a wider range of users, the number of ways in which IEDB-AR can be accessed has been expanded. Specifically, the predictive tools can be programmatically accessed using a web interface and can also be downloaded as software packages.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gks438