Spectral-domain OCT in anti-VEGF treatment of myopic choroidal neovascularization

Purpose To evaluate changes in macular morphology due to myopic choroidal neovascularization (CNV), using spectral-domain optical coherence tomography (SD-OCT). Methods In all, 22 eyes with recent-onset untreated CNV underwent 1 intravitreal injection of anti-vascular endothelial growth factor (anti...

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Bibliographic Details
Published in:Eye (London) 2012-07, Vol.26 (7), p.976-982
Main Authors: Introini, U, Casalino, G, Querques, G, Gimeno, A T, Scotti, F, Bandello, F
Format: Article
Language:English
Subjects:
692/1807/1482
692/699
692/700/1421/1846
692/700/565
Adult
Aged
Angiogenesis Inhibitors - therapeutic use
Biological and medical sciences
Choroidal Neovascularization - drug therapy
Choroidal Neovascularization - metabolism
Choroidal Neovascularization - pathology
Clinical Study
Female
Fluorescein - metabolism
Humans
Laboratory Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Miscellaneous
Myopia - complications
Ophthalmology
Pharmaceutical Sciences/Technology
Prospective Studies
Sensitivity and Specificity
Surgery
Surgical Oncology
Tomography, Optical Coherence - methods
Tomography, Optical Coherence - standards
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Vision disorders
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Summary:Purpose To evaluate changes in macular morphology due to myopic choroidal neovascularization (CNV), using spectral-domain optical coherence tomography (SD-OCT). Methods In all, 22 eyes with recent-onset untreated CNV underwent 1 intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF), followed by a pro-re-nata regimen. SD-OCT was performed at baseline (before first administration of anti-VEGF treatment) and month 1, and 2; macular morphologic changes and outer retina characteristics (SD-OCT findings) associated with CNV activity were evaluated. Sensitivity and specificity were calculated for SD-OCT findings using fluorescein angiography (FA) as standard reference. Results Mean central retinal thickness (CRT) showed no significant reduction from baseline (284±98  μ m) to month 1 (257±74  μ m) and month 2 (263±72  μ m). A hyper-reflective lesion with fuzzy borders (fuzzy area), and ‘absent or altered’ IS/OS junction were the only SD-OCT findings associated with CNV activity ( P
ISSN:0950-222X
1476-5454
DOI:10.1038/eye.2012.75