Early recognition of the 2009 pandemic influenza A (H1N1) pneumonia by chest ultrasound

• Published in: Critical care (London, England) England), 2012-02, Vol.16 (1), p.R30-R30, Article R30
• Main Authors: Testa, Americo, Soldati, Gino, Copetti, Roberto, Giannuzzi, Rosangela, Portale, Grazia, Gentiloni-Silveri, Nicolò
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Early Diagnosis; Female; Humans; Influenza A Virus, H1N1 Subtype - isolation & purification; Influenza, Human - diagnostic imaging; Influenza, Human - epidemiology; Influenza, Human - virology; Male; Middle Aged; Pandemics; Pneumonia, Viral - diagnostic imaging; Pneumonia, Viral - epidemiology; Pneumonia, Viral - virology; Ultrasonography - methods
• ISSN: 1364-8535; 1466-609X; 1364-8535
• DOI: 10.1186/cc11201

The clinical picture of the pandemic influenza A (H1N1)v ranges from a self-limiting afebrile infection to a rapidly progressive pneumonia. Prompt diagnosis and well-timed treatment are recommended. Chest radiography (CRx) often fails to detect the early interstitial stage. The aim of this study was to evaluate the role of bedside chest ultrasonography (US) in the early management of the 2009 influenza A (H1N1)v infection. 98 patients who arrived in the Emergency Department complaining of influenza-like symptoms were enrolled in the study. Patients not displaying symptoms of acute respiratory distress were discharged without further investigations. Among patients with clinical suggestion of a community-acquired pneumonia, cases encountering other diagnoses or comorbidities were excluded from the study. Clinical history, laboratory tests, CRx, and computed tomography (CT) scan, if indicated, contributed to define the diagnosis of pneumonia in the remaining patients. Chest US was performed by an emergency physician, looking for presence of interstitial syndrome, alveolar consolidation, pleural line abnormalities, and pleural effusion, in 34 patients with a final diagnosis of pneumonia, in 16 having normal initial CRx, and in 33 without pneumonia, as controls. Chest US was carried out without discomfort in all subjects, requiring a relatively short time (9 minutes; range, 7 to 13 minutes). An abnormal US pattern was detected in 32 of 34 patients with pneumonia (94.1%). A prevalent US pattern of interstitial syndrome was depicted in 15 of 16 patients with normal initial CRx, of whom 10 (62.5%) had a final diagnosis of viral (H1N1) pneumonia. Patients with pneumonia and abnormal initial CRx, of whom only four had a final diagnosis of viral (H1N1) pneumonia (22.2%; P