Sensitive Biological Detection with a Soluble and Stable Polymeric Paramagnetic Nano Cluster

We describe the design, synthesis and biological characterization of manganese oxocluster-based “single molecule magnets (SMMs)”. We demonstrate that polymeric micellar nanoparticles can serve as a carrier and help to stabilize delicate SMM molecules from breaking down easily and thus prevent their...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2012-06, Vol.134 (25), p.10377-10380
Main Authors: Kim, Benjamin, Schmieder, Anne H., Stacy, Allen J., Williams, Todd A., Pan, Dipanjan
Format: Article
Language:English
Online Access:Get full text
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Summary:We describe the design, synthesis and biological characterization of manganese oxocluster-based “single molecule magnets (SMMs)”. We demonstrate that polymeric micellar nanoparticles can serve as a carrier and help to stabilize delicate SMM molecules from breaking down easily and thus prevent their property loss. Concentrating thousands of Mn-clusters per micelle provided a high ionic and per-particle relaxivity allowing sensitive MR imaging in vivo . This reports one of the earliest examples of in vivo imaging of a rationally designed polymeric micelles that features SMM.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja3040366