Palindromic sequences are associated with sites of DNA breakage during gene conversion

Gene conversion is a recombinatorial mechanism which transfers genetic information from a donor into a recipient gene. A case of gene conversion between inmunoglobulin Vg region genes was analysed and palindromic sequences were found to be located near to the left recombinatorial breakpoint, which a...

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Bibliographic Details
Published in:Nucleic acids research 1986-05, Vol.14 (9), p.3871-3882
Main Authors: Krawinkel, U., Zoebelein, G., Bothwell, A. L. M.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene Conversion
Genic rearrangement. Recombination. Transposable element
Immunoglobulin Heavy Chains - genetics
Immunoglobulin Variable Region - genetics
Mice
Molecular and cellular biology
Molecular genetics
Nucleic Acid Conformation
Recombination, Genetic
Repetitive Sequences, Nucleic Acid
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Summary:Gene conversion is a recombinatorial mechanism which transfers genetic information from a donor into a recipient gene. A case of gene conversion between inmunoglobulin Vg region genes was analysed and palindromic sequences were found to be located near to the left recombinatorial breakpoint, which also is flanked by a direct repeat sequence. We performed a computer search for palindromes and direct repeats in the published sequences of eucaryotic genes which had been involved in gene conversion. In these sequences, the palindrome with the best or second best quality is located near to a breakpoint of recombination. A correlation of recombination breakpoints with direct repeats was not observed. This suggests that gene conversion is promoted by palindromic sequences.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/14.9.3871