A perspective on the selection of unrelated donors and cord blood units for transplantation

Selection of a suitable graft for allogeneic hematopoietic stem cell transplantation involves consideration of both donor and recipient characteristics. Of primary importance is sufficient donor-recipient HLA matching to ensure engraftment and acceptable rates of GVHD. In this Perspective, the Natio...

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Bibliographic Details
Published in:Blood 2012-07, Vol.120 (2), p.259-265
Main Authors: Spellman, Stephen R., Eapen, Mary, Logan, Brent R., Mueller, Carlheinz, Rubinstein, Pablo, Setterholm, Michelle I., Woolfrey, Ann E., Horowitz, Mary M., Confer, Dennis L., Hurley, Carolyn K.
Format: Article
Language:English
Subjects:
Adult
Adult Stem Cells - transplantation
Biological and medical sciences
Cord Blood Stem Cell Transplantation - standards
Donor Selection - standards
Donor Selection - statistics & numerical data
Hematologic and hematopoietic diseases
Hematopoietic Stem Cell Transplantation - standards
Histocompatibility Testing
Humans
Infant, Newborn
Medical sciences
Peripheral Blood Stem Cell Transplantation - standards
Tissue Donors
Transplantation Immunology
United States
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Summary:Selection of a suitable graft for allogeneic hematopoietic stem cell transplantation involves consideration of both donor and recipient characteristics. Of primary importance is sufficient donor-recipient HLA matching to ensure engraftment and acceptable rates of GVHD. In this Perspective, the National Marrow Donor Program and the Center for International Blood and Marrow Transplant Research provide guidelines, based on large studies correlating graft characteristics with clinical transplantation outcomes, on appropriate typing strategies and matching criteria for unrelated adult donor and cord blood graft selection.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2012-03-379032